The depiction of science and technology in film, novels, television, games, and other media directly informs and affects the work of real-world scientists; while the authors of these narrative forms are driven to incorporate the ideas and artifacts of modern and projected technology. It's an ever-tighter feedback loop, and each side is sprinting to keep up with the other. Through it all runs a new generation of digital tools that is inexorably changing the creative process - of media author and scientist alike. This panel discusses what it means for science and design in narrative to embrace, incorporate, mutate, pervert, extrapolate, and refine each other.