Once denigrated as "meatspace," the physical world and the messy bodies that inhabit it continue to matter in the stories we tell, the ideas we engage and the relationships we form. While biological metaphors abound in our attempts to understand the rise of digital media, these obscure as much as they reveal, sometimes even diminishing our clarity on the impact of technology on social behavior and community structures. Similarly, our attempts to quantify the self and to create "bio-informatics" that measure, visualize, track and assess the body inspires enthusiasm and anxiety alike. Derived from the verb "informare" meaning "to give form to the mind,” information intersects with biology in compelling ways. The biology of fiction asks us to think about how to measure, test, visualize and empirically validate the methods and outcomes of fiction as a complement of the creative process.