While photographic and cinematographic images increasingly resemble computer generated ones and computer images asymptotically approach "photorealism," the line between "real" and "virtual" seems blurrier than ever. But image perception is only as important as the content it represents. This theme is not meant as an invitation to revisit well-worn ‘video vs. film’ or ‘analogue vs. digital’ debates, but to catalyze a discussion of the realities of Science as revealed in Fiction and the perceived realities of Science as a result of Fiction. At stake is our fundamental relation to reality and the ease with which data spaces increasingly serve as flexible and evocative narrative spaces.